ZO Peptide Facial Refining Concentrate - now available in clinic

Product Overview

Peptide Facial Refining Concentrate is ZO Skin Health’s advanced anti-ageing serum launched in September 2025, designed to complement the visible effects of neurotoxins and dermal fillers while also functioning as a powerful standalone treatment. This concentrated formula targets multiple signs of ageing through four cutting-edge peptide technologies, clinically proven to deliver a more sculpted appearance and refined facial geometry in just 12 weeks.​​

Key Benefits

Targets Wrinkles and Volume Loss: The formula addresses both visible expression lines (dynamic wrinkles) and static wrinkles whilst restoring the appearance of lost volume, creating a visibly lifted and more refined appearance.​

Complements Injectable Treatments: Designed to work synergistically with neurotoxins (like Botox) and dermal fillers, helping patients maintain results between clinic visits whilst delivering visible improvements on its own.​

Supports Skin Structure: The Refining Peptide Complex improves the appearance of skin’s structural integrity, promoting more sculpted facial geometry. The Volumizing Tripeptide supports the skin’s natural production of hyaluronic acid for a plumper, fuller look.​

Reduces Visible Redness: The exclusive ZPOLY™ Complex helps to alleviate visible redness and fortify the skin’s protective barrier.​

Clinical Results

In a 12-week independent clinical study involving 49 participants aged 47-72 with Fitzpatrick skin types I-VI:

• 92% saw a reduction in the appearance of fine lines

• 84% reported visibly younger-looking facial geometry (a more sculpted, balanced face overall)

• 86% saw improvement in facial hollow areas (places that had lost fullness)

• 82% experienced reduced forehead wrinkles

• 96% said their skin felt smoother​

Additional measurements showed:​

• 10% reduction in wrinkle volume after 4 weeks

• 11% improvement in visible skin texture after 12 weeks

• 8% improvement in skin firmness and elasticity after 2 weeks

• 12% improvement in elasticity by week 12

• 100% of subjects showed improvement in skin hydration by week 4

Advanced Peptide Technologies

The formula is powered by four cutting-edge peptide technologies:​

1. Acetyl Octapeptide-3

• Contains 8 amino acids

• Targets the appearance of dynamic lines and wrinkles, especially around the forehead and eye area

• Functions as a neuropeptide to modulate wrinkle formation​

2. Acetyl Hexapeptide-8

• Contains 6 amino acids

• Works synergistically with Acetyl Octapeptide-3

• Provides greater precision in smoothing the appearance of deeper dynamic and static wrinkles​

3. Refining Peptide Complex

• Blend of 2 active peptides: Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine and Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

• Supports a visibly more refined facial geometry

• Improves the appearance of skin’s structural integrity​

4. Volumizing Tripeptide (Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate)

• A unique tri-peptide

• Supports the skin’s natural production of hyaluronic acid for fuller, plumper-looking skin

• Helps restore the appearance of lost volume​

ZPOLY™ Complex

This ZO-exclusive, plant-derived polysaccharide complex is a blend of four polysaccharide extracts:​

• Laminaria digitata (brown seaweed) extract

• Opuntia ficus-indica (prickly pear) stem cell extract

• Schizophyllan (mushroom)

• Galactoarabinan (larch tree)

Benefits: Helps prevent premature signs of ageing, supports skin barrier restoration, boosts extended hydration after a single application, and minimises the visible appearance of redness and blotchiness for a calm skin tone.​

Full Ingredient List

Aqua/Water/Eau, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, PEG-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Phospholipids, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus/Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Fragrance (Parfum), Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Vegetable Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol.​

Formulation Properties

• Alcohol-free and fragrance-free (though some sources list “Fragrance (Parfum)” in the full ingredient list)​

• Silicone-based serum with a lightweight, smooth texture

• Suitable for all skin types

• Makes it a perfect complement to injectable procedures​

How to Use

Application: Apply 1-2 pumps to clean, dry skin​

Frequency: Morning and/or evening.​

Routine Placement: Apply before moisturiser for maximum results. As a treatment serum, it should be applied after cleansing and toning but before heavier creams or SPF​

Product Pairing: Can be further complemented with Firming Serum and AOX Serum for enhanced anti-ageing results​

Ideal Candidates

This serum is particularly beneficial for those who:​

• Are experiencing both dynamic lines (from facial movement) and static lines (wrinkles visible when the face is relaxed)

• Have signs of lost volume (around cheeks, under the eyes, or facial hollows) and want plumping effects without immediately resorting to fillers

• Would like to maintain or prolong results from treatments like fillers or Botox

• Want to improve skin texture, firmness, and contour over time

• Are seeking a high-performance anti-ageing solution with clinical backing

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