Polynucleotide treatments are minimally invasive procedures where the product is injected directly into the skin using tiny needles. The technique and depth of injection vary depending on the specific area being treated, for instance, around the eyes, face, neck or other regions.

Polynucleotide injections are considered very safe when performed by qualified medical professionals. The products used are biocompatible, meaning they work harmoniously with your body’s natural tissues. Side effects are generally mild and temporary, such as slight swelling, redness or bruising. There is a very low risk of allergic reactions and all of our treatments are administered in regulated environments.

Polynucleotide treatments are suitable for most individuals looking to improve skin quality, reduce fine lines, address dullness or support healing of sun-damaged or acne-scarred skin. However, treatment is not recommended if you are pregnant, breastfeeding or have active skin infections or allergies to specific ingredients. We will advise you to avoid extreme temperatures, such as saunas or very cold weather, for around 7 days post-treatment.

While hyaluronic acid-based products like Profhilo and dermal fillers work by hydrating or volumising the skin, polynucleotides work by stimulating your skin’s natural regeneration process. They act as biostimulators that activate fibroblasts to increase the production of collagen and elastin. Unlike fillers that give immediate volume, polynucleotides improve skin texture, elasticity and tone over time by supporting deeper tissue repair and cellular health.

Downtime is typically minimal. You may experience mild redness, swelling or slight bruising, which generally subsides within 12 to 24 hours. You can usually return to normal activities the following day with little to no disruption.

The first signs of improvement often begin around 7-10 days after your first treatment, with the full effects visible at around 3 weeks. This is when we recommend your second and subsequent treatments to take place. By doing so, we maintain continued, active stimulation of fibroblast production, maximising short and long-term results.

First your medical history will be taken followed by an examination of your skin concerns. You can discuss whether polynucleotide treatment is suitable for you and address your expectations from treatment. When the treatment has been fully explained you will be required to sign a consent form and a photograph will be taken for your confidential records.

Following cleansing local anaesthetic can be applied if needed.

Polynucleotide treatment will then commence with intra-dermal micro bolus injection or via cannula.

Following treatment you an antiseptic cream or lotion will be applied, normally Clinisept+

Treatment is a safe and effective way of tightening and hydrating your skin.

Your comfort levels and expectations are important factors which are considered in your consultation.

Polynucleotide treatment is commonly used on the following areas

• Face
• Neck
• Décolleté

However, it may be considered also for:

• Hair
• Hands
• Abdomen
• Thighs
• Inner knees
• Inner arms
• Stretch marks

For other treatment areas please discuss with Dr Anna Hemming

Treatment is offered as a 4 session course (using 2ml per session) with 3 week intervals between treatments.

Larger areas can be treated during a course, however more product is needed which is reflected in the price.

We also combine Polynucleotide treatments with Profhilo for maximum results.

Dr Hemming will be able to discuss the options most suitable for your skin concerns following examination.

Side effects are minimal if any. Injection site tenderness and mild bruising may occur.

It should not to be used if pregnant or breast feeding as we have no research to prove it is safe for your foetus or child.

Care must be taken if diagnosed with neurological or bleeding disorders, currently suffering with a skin infection or allergy or taking particular medication. Your specialist will be able to advise you further.

Please discuss any current medication with the doctor, especially if you are taking aspirin on Ibuprofen. Medication may need to be stopped before treatment.

• There may be some tenderness, redness, swelling and bruising around the injection site. This is normal and will subside, usually within a few days (or hours).
• If swelling or pain persists or you are concerned, please contact the clinic as soon as possible.
• Use a cold pack to reduce swelling and /or redness.
• Do not massage or manipulate the treated area.
• Apply a SPF 30+ sun screen. Recommended ZO skin health SPF 30 + primer, or ZO Skin Health Sheer SPF50.
• Stay hydrated
• No recover times is required and you can return to your daily activities immediately.
• Avoid any further cosmetic procedures for 2 days after treatment.
• Avoid wearing make up for 12 hours post treatment
• Avoid extreme temperatures (hot and cold) for a minimum of 7 days after treatment (no saunas, steam rooms, sun beds or sun exposure).
• Avoid touching treatment area without first cleaning hands (can use Clinicsept+)
• Avoid strenuous exercise for 24 hours
• Avoid Swimming for 48 hours
• Avoid alcohol for 24 hours after treatment

Ensure you have booked your second treatment 21 days after the first and a follow up 21 days after your second treatment.

Further booster sessions or courses will maintain the results.

If you have any concerns following treatment with Profhilo please contact Dr Hemming immediately.